------------------------------------------------------------------------------ SWISS-PROT Protein Sequence Data Bank. Release 36.0, July 1998 ------------------------------------------------------------------------------ Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT ------------------------------------------------------------------------------ Amos Bairoch Email: bairoch@medecine.unige.ch Swiss Institute of Bioinformatics and University of Geneva Switzerland ------------------------------------------------------------------------------ Document name: GLYCOSID.TXT ------------------------------------------------------------------------------ This documents provides both a brief description of the classification of glycosyl hydrolases into families as developed by Bernard Henrissat as well as the list, classified by family, of the glycosyl hydrolases entries in SWISS-PROT Comments about the glycosyl hydrolases families classification should be sent to: Bernard Henrissat AFMB-CNRS 31 Chemin Joseph Aiguier 13402 Marseille cedex 20 France E-mail: bernie@afmb.cnrs-mrs.fr ============================ Glycosyl hydrolases families ============================ Introduction ------------ O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes which hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non-carbohydrate moiety. The IUB-MB Enzyme nomenclature of glycosyl hydrolases is based on their substrate specificity and occasionally on their molecular mechanism; such a classification does not reflect (and was not intended to) the structural features of these enzymes. A classification of glycosyl hydrolases in families based on amino acid sequence similarities has been proposed a few years ago. Because there is a direct relationship between sequence and folding similarities, such a classification is expected to: (i) reflect the structural features of these enzymes better than their sole substrate specificity, (ii) help to reveal the evolutionary relationships between these enzymes and (iii) provide a convenient tool to derive mechanistic information [1-2]. This document provides an updated list of the glycosyl hydrolase families. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans' (i) when new sequences are found to be related to more than one family, (ii) when the sensitivity of sequence comparison methods is increased or (iii) when structural determinations demonstrate the resemblance between members of different families [3]. The established 'clans' are also listed in this document. Catalytic mechanism ------------------- Enzymatic hydrolysis of the glycosidic bond takes place via general acid catalysis that requires two critical residues: a proton donor and a nucleophile/base [4]. This hydrolysis occurs via two major mechanisms giving rise to either an overall retention, or an inversion, of anomeric configuration. For each families listed in this document we indicate, when it is known, the stereochemical outcome of the reaction catalyzed as well as the type of amino-acid residues acting as a nucleophile/base and as a proton donor. Clans ----- Name Families belonging to the clan ---- ------------------------------ GH-A 1,2,5,10,17,26,30,35,39,42,53 GH-B 7,16 GH-C 11,12 GH-D 27,36 GH-E 33,34 Note ---- Some glycosyl hydrolases are multifunctional enzymes that contain catalytic domains that belong to different GH families. The SWISS-PROT entries for these proteins are therefore mentionned in each of the relevant list of family members. References ---------- [ 1] Henrissat B. A classification of glycosyl hydrolases based on amino-acid sequence similarities. Biochem. J. 280:309-316(1991). [ 2] Henrissat B., Bairoch A. New families in the classification of glycosyl hydrolases based on amino- acid sequence similarities. Biochem. J. 293:781-788(1993). [ 3] Henrissat B., Bairoch A. Updating the sequence-based classification of glycosyl hydrolases. Biochem. J. 316:695-696(1996). [ 4] Davies G., Henrissat B. Structures and mechanisms of glycosyl hydrolases. Structure 3:853-859(1995). --------------------------------------------------------------- ========================================== SWISS-PROT entries for glycosyl hydrolases ========================================== ======== Family 1 ======== Description: Mainly beta-glucosidases (EC 3.2.1.21); 6-phospho-beta- galactosidases (EC 3.2.1.85); 6-phospho-beta-glucosidases (EC 3.2.1.86); lactase-phlorizin hydrolases (EC 3.2.1.108); and myrosinases (EC 3.2.3.1). PROSITE: PDOC00495 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Glu (experimental) Catalytic proton donor: Glu (experimental) but absent in myrosinases Clan: GH-A. Known taxonomic range: eukaryotae, prokaryotae, archaea. ABGA_CLOLO (Q46130), ARBB_ERWCH (P26206), ASCB_ECOLI (P24240), BGAL_SULSH (P50388), BGAL_SULSO (P14288), BGAM_SULSO (P22498), BGL1_BACSU (P40740), BGL2_BACSU (P42403), BGLA_BACCI (Q03506), BGLA_BACSU (P42973), BGLA_CLOTM (P26208), BGLA_ECOLI (Q46829), BGLA_ERWHE (Q59437), BGLA_PAEPO (P22073), BGLA_THEMA (Q08638), BGLB_ECOLI (P11988), BGLB_MICBI (P38645), BGLB_PAEPO (P22505), BGLC_MAIZE (P49235), BGLS_AGRSP (P12614), BGLS_CALSA (P10482), BGLS_TRIRP (P26204), BGLT_TRIRP (P26205), CASB_KLEOX (Q48409), LACG_LACAC (P50977), LACG_LACCA (P14696), LACG_LACLA (P11546), LACG_STAAU (P11175), LACG_STRMU (P50978), LPH_HUMAN (P09848), LPH_RABIT (P09849), LPH_RAT (Q02401), MYR1_SINAL (P29737), MYR2_SINAL (P29738), MYR3_SINAL (P29092), MYRA_SINAL (P29736), MYRO_ARATH (P37702), MYRO_BRANA (Q00326) ======== Family 2 ======== Description: Mainly beta-galactosidases (EC 3.2.1.23), beta-glucuronidases (EC 3.2.1.31) and beta-mannosidases (EC 3.2.1.25). PROSITE: PDOC00531 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Glu (experimental) Catalytic proton donor: Glu (experimental) Clan: GH-A. Known taxonomic range: eukaryotae, prokaryotae. BGA2_ECOLI (P06864), BGAL_AGRRD (P30812), BGAL_CLOAB (P24131), BGAL_ECOLI (P00722), BGAL_KLEPN (P06219), BGAL_KLULA (P00723), BGAL_LACDE (P20043), BGAL_LEULA (Q02603), BGAL_STRTR (P23989), BGAL_THETU (P26257), BGLR_ECOLI (P05804), BGLR_HUMAN (P08236), BGLR_MOUSE (P12265), BGLR_RAT (P06760), BLGR_CANFA (O18835), MANB_BOVIN (Q29444), MANB_CAEEL (Q93324), MANB_CAPHI (Q95327), MANB_HUMAN (O00462) ======== Family 3 ======== Description: Mainly beta-glucosidases (EC 3.2.1.21). PROSITE: PDOC00621 3D structure status: Not available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae, prokaryotae. Note: an Asp is proposed as a catalytic residue, but it is not known if it is the nucleophile or the proton donor. BGL1_ASPAC (P48825), BGL1_SACFI (P22506), BGL2_SACFI (P22507), BGL3_ASPWE (P29090), BGLB_CLOTM (P14002), BGLS_AGRTU (P27034), BGLS_BUTFI (P16084), BGLS_HANAN (P06835), BGLS_KLUMA (P07337), BGLS_RUMAL (P15885), BGLS_SCHCO (P29091), BGLX_ECOLI (P33363), BGLX_ERWCH (Q46684), BGLX_SALTY (Q56078), HEX2_VIBFU (P96157), HEXA_ALTSO (P48823), YBBD_BACSU (P40406), YCFO_ECOLI (P75949), YCFO_HAEIN (P44955) ======== Family 4 ======== Description: Mostly bacterial 6-phospho-beta-glucosidase (EC 3.2.1.86). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: prokaryotae. AGAL_ECOLI (P06720), AGAL_SALTY (P30877), CELF_BACSU (P46320), CELF_ECOLI (P17411), GLVG_BACSU (P54716), GLVG_ECOLI (P31450), LPLD_BACSU (P39130) ======== Family 5 ======== Description: Mainly endoglucanases (EC 3.2.1.4). Contains also beta-mannanases (EC 3.2.1.78) and exo-1,3-glycanases (EC 3.2.1.58). PROSITE: PDOC00565 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Glu (experimental) Catalytic proton donor: Glu (experimental) Clan: GH-A Known taxonomic range: eukaryotae, prokaryotae. Note: formerly known as cellulase family A. EXG1_YEAST (P23776), EXG2_YEAST (P52911), EXGH_SCHPO (Q10444), EXG_CANAL (P29717), EXG_YARLI (Q12725), GUN1_ACICE (P54583), GUN1_BACS4 (P06566), GUN1_BACSU (P07983), GUN1_BUTFI (P20847), GUN1_CRYFL (Q04469), GUN1_RUMAL (P16216), GUN2_BACS4 (P06565), GUN2_BACSU (P10475), GUN2_TRIRE (P07982), GUN3_BACS4 (P19570), GUN3_BACSU (P23549), GUN3_FIBSU (P14250), GUN4_RUMAL (Q07940), GUN5_THEFU (Q01786), GUNA_BUTFI (P22541), GUNA_CLOCE (P17901), GUNA_CLOLO (P54937), GUNA_RUMAL (P23660), GUNA_RUMFL (P16169), GUNA_STRLI (P27035), GUNA_XANCP (P19487), GUNB_CALSA (P10474), GUNB_CLOCL (P28621), GUNB_CLOTM (P04956), GUNB_NEOPA (Q12647), GUNB_PAELA (P23550), GUNB_RUMAL (P23661), GUNC_CLOSF (P23340), GUNC_CLOTM (P07985), GUNC_PSEFL (P27033), GUND_CELFI (P50400), GUND_CLOCE (P25472), GUND_CLOCL (P28623), GUNE_CLOTM (P10477), GUNG_CLOTM (Q05332), GUNH_CLOTM (P16218), GUNN_ERWCA (Q59394), GUNV_ERWCA (Q47096), GUNW_ERWCA (Q59395), GUNZ_ERWCH (P07103), GUN_BACS1 (P06564), GUN_BACS6 (P19424), GUN_BURSO (P17974), GUN_CLOAB (P15704), GUN_PAEPO (P23548), GUN_ROBSP (P23044), GUN_SCHCO (P81190), MANA_STRLI (P51529), MANB_CALSA (P22533), SPR1_YEAST (P32603), YBQ6_YEAST (P38081), YIS7_YEAST (P40566) ======== Family 6 ======== Description: Endoglucanases (EC 3.2.1.4) and cellobiohydrolases (EC 3.2.1.91). PROSITE: PDOC00563 3D structure status: Available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: Asp (experimental) Catalytic proton donor: Asp (experimental) Clan: None Known taxonomic range: eukaryotae, prokaryotae. Note: formerly known as cellulase family B. GUN1_STRHA (P33682), GUN1_STRSQ (P13933), GUN2_THEFU (P26222), GUNA_CELFI (P07984), GUNA_MICBI (P26414), GUNB_FUSOX (P46236), GUX2_TRIRE (P07987), GUX3_AGABI (P49075), GUXA_CELFI (P50401) ======== Family 7 ======== Description: Endoglucanases (EC 3.2.1.4) and cellobiohydrolases (EC 3.2.1.91). PROSITE: None 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Glu (experimental) Catalytic proton donor: Glu (experimental) Clan: GH-B Known taxonomic range: eukaryotae. Note: formerly known as cellulase family C. GUN1_HUMGR (Q12622), GUN1_TRILO (Q12714), GUN1_TRIRE (P07981), GUNC_FUSOX (P46237), GUX1_HUMGR (P15828), GUX1_NEUCR (P38676), GUX1_PENJA (Q06886), GUX1_PHACH (P13860), GUX1_TRIRE (P00725), GUX1_TRIVI (P19355), GUXC_FUSOX (P46238) ======== Family 8 ======== Description: Mostly endoglucanases (EC 3.2.1.4). PROSITE: PDOC00640 3D structure status: Available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: Asp (inferred) Catalytic proton donor: Glu (experimental) Clan: None Known taxonomic range: prokaryotae. Note: formerly known as cellulase family D. GUB_BACCI (P19254), GUN2_CLOJO (P37701), GUNA_ACEXY (P37696), GUNA_CLOTM (P04955), GUNC_CLOCE (P37699), GUNY_ERWCH (P27032), GUN_BACSP (P29019), GUN_CELUD (P18336), YHJM_ECOLI (P37651) ======== Family 9 ======== Description: Mostly endoglucanases (EC 3.2.1.4). PROSITE: PDOC00511 3D structure status: Available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: Asp (experimental) Catalytic proton donor: Glu (experimental) Clan: None Known taxonomic range: eukaryotae, prokaryotae. Note: formerly known as cellulase family E. GUN1_PERAE (P05522), GUN1_STRRE (Q05156), GUN2_PERAE (P23666), GUN4_THEFU (P26221), GUN6_DICDI (P22699), GUNA_CALSA (P22534), GUNA_FIBSU (P23665), GUNA_PSEFL (P10476), GUNB_CELFI (P26225), GUNC_BUTFI (P23658), GUNC_CELFI (P14090), GUNC_CLOCL (P28622), GUND_CLOTM (P04954), GUNF_CLOTM (P26224), GUNG_CLOCE (P37700), GUNI_CLOTM (Q02934), GUNX_PRUPE (P38534), GUNZ_CLOSR (P23659), GUN_PHAVU (P22503) ========= Family 10 ========= Description: Mostly xylanases (EC 3.2.1.8). PROSITE: PDOC00510 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Glu (experimental) Catalytic proton donor: Glu (experimental) Clan: GH-A Known taxonomic range: eukaryotae, prokaryotae. Note: formerly known as cellulase family F. CEXY_CLOSR (P40942), GUNB_CALSA (P10474), GUNF_FUSOX (P46239), GUX_CELFI (P07986), XYN1_BACST (P40943), XYN2_BACST (P45703), XYN4_CALSA (P23557), XYNA_ASPAK (P33559), XYNA_BACOV (P49942), XYNA_BACS5 (P07528), XYNA_BUTFI (P23551), XYNA_CALSA (P23556), XYNA_CRYAL (P07529), XYNA_DICB4 (P80718), XYNA_DICTH (Q12603), XYNA_PENCH (P29417), XYNA_PRERU (P48789), XYNA_PSEFL (P14768), XYNA_RUMFL (P29126), XYNA_STRLI (P26514), XYNA_THEAU (P23360), XYNA_THEMA (Q60037), XYNA_THENE (Q60042), XYNA_THER8 (P40944), XYNA_THESA (P36917), XYNB_BUTFI (P26223), XYNB_DICB4 (P80717), XYNB_PSEFL (P23030), XYNB_THENE (Q60041), XYNX_CLOTM (P38535), XYNY_CLOTM (P51584), XYNZ_CLOTM (P10478) ========= Family 11 ========= Description: Mostly xylanases (EC 3.2.1.8). PROSITE: PDOC00622 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Glu (experimental) Catalytic proton donor: Glu (experimental) Clan: GH-C Known taxonomic range: eukaryotae, prokaryotae. Note: formerly known as cellulase family G. XYN1_ASPAW (P55328), XYN1_ASPNG (P55329), XYN1_ASPTU (P55331), XYN1_COCCA (Q06562), XYN1_EMENI (P55332), XYN1_HUMIN (P55334), XYN1_TRIRE (P36218), XYN2_ASPNG (P55330), XYN2_EMENI (P55333), XYN2_MAGGR (P55335), XYN2_TRIRE (P36217), XYN3_ASPAK (P33557), XYNA_BACCI (P09850), XYNA_BACPU (P00694), XYNA_BACST (P45705), XYNA_BACSU (P18429), XYNA_CLOAB (P17137), XYNA_CLOSR (P33558), XYNA_NEOPA (P29127), XYNA_PIRSP (Q12667), XYNA_RUMFL (P29126), XYNA_SCHCO (P35809), XYNB_ASPAK (P48824), XYNB_STRLI (P26515), XYNC_FIBSU (P35811), XYNC_STRLI (P26220), XYND_CELFI (P54865), XYND_RUMFL (Q53317), XYN_TRIHA (P48793) ========= Family 12 ========= Description: Endoglucanases (EC 3.2.1.4). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Glu (inferred) Catalytic proton donor: Glu (inferred) Clan: GH-C Known taxonomic range: eukaryotae, prokaryotae. Note: formerly known as cellulase family H. GUNA_ASPAK (Q12679), GUNS_ERWCA (P16630), GUN_ASPAC (P22669) ========= Family 13 ========= Description: Mostly alpha-amylases (EC 3.2.1.1); pullulanases (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93). PROSITE: None 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Asp (experimental) Catalytic proton donor: Glu (experimental) Clan: None Known taxonomic range: eukaryotae, prokaryotae. AGL_PEDPE (P43473), AM2A_ORYSA (P27935), AM3A_ORYSA (P27932), AM3B_ORYSA (P27937), AM3C_ORYSA (P27939), AM3D_ORYSA (P27933), AM3E_ORYSA (P27934), AMC1_ORYSA (P27940), AMC2_ORYSA (P27941), AMT4_PSESA (P22963), AMT4_PSEST (P13507), AMT6_BACS7 (P19571), AMY1_AEDAE (P53354), AMY1_AERHY (P22630), AMY1_DEBOC (P19269), AMY1_ECOLI (P25718), AMY1_HORVU (P00693), AMY1_ORYSA (P17654), AMY1_SACFI (P21567), AMY1_SCHPO (Q09840), AMY2_DICTH (P14898), AMY2_ECOLI (P26612), AMY2_HORVU (P04063), AMY2_SALTY (P26613), AMY2_SCHPO (O14154), AMY3_DICTH (P14899), AMY3_HORVU (P04747), AMY3_WHEAT (P08117), AMY4_HORVU (P04748), AMY5_HORVU (P04749), AMY6_HORVU (P04750), AMYA_AERHY (P41131), AMYA_ASPAW (Q02905), AMYA_ASPNG (P56271), AMYA_ASPOR (P10529), AMYA_DROMA (P54215), AMYA_DROME (P08144), AMYA_DROYA (P51548), AMYA_VIGMU (P17859), AMYB_ASPAW (Q02906), AMYB_PAEPO (P21543), AMYC_HUMAN (P19961), AMYM_BACAD (P32818), AMYM_BACLI (Q04977), AMYM_BACST (P19531), AMYP_HUMAN (P04746), AMYP_MOUSE (P00688), AMYP_PIG (P00690), AMYP_RAT (P00689), AMYR_BACS8 (P17692), AMYS_HUMAN (P04745), AMYS_MOUSE (P00687), AMY_ALTHA (P29957), AMY_ASPSH (P30292), AMY_BACAM (P00692), AMY_BACCI (P08137), AMY_BACLI (P06278), AMY_BACME (P20845), AMY_BACST (P06279), AMY_BACSU (P00691), AMY_BUTFI (P30269), AMY_CLOAB (P23671), AMY_DERPT (P49274), AMY_STRGR (P30270), AMY_STRHY (P08486), AMY_STRLI (Q05884), AMY_STRLM (P09794), AMY_STRTL (P27350), AMY_STRVL (P22998), AMY_THECU (P29750), AMY_THETU (P26827), AMY_TRICA (P09107), APU_THEET (P38939), APU_THESA (P36905), APU_THETU (P38536), APU_THETY (P16950), CDAS_BACSH (Q08341), CDAS_THEET (P29964), CDG1_PAEMA (P04830), CDG2_PAEMA (P31835), CDGT_BACCI (P30920), CDGT_BACLI (P14014), CDGT_BACOH (P27036), CDGT_BACS0 (P05618), CDGT_BACS2 (P31746), CDGT_BACS3 (P09121), CDGT_BACSP (P30921), CDGT_BACSS (P31747), CDGT_BACST (P31797), CDGT_KLEPN (P08704), CDGU_BACCI (P43379), DEXB_STREQ (Q59905), DEXB_STRMU (Q99040), DEXB_STRPN (Q54796), GLGB_AGRTU (P52979), GLGB_BACCL (P30537), GLGB_BACST (P30538), GLGB_BACSU (P39118), GLGB_BUTFI (P30539), GLGB_ECOLI (P07762), GLGB_HAEIN (P45177), GLGB_HUMAN (Q04446), GLGB_MAIZE (Q08047), GLGB_MYCTU (Q10625), GLGB_ORYSA (Q01401), GLGB_SOLTU (P30924), GLGB_STRAU (P52980), GLGB_SYNP7 (P16954), GLGB_SYNY3 (P52981), GLGB_YEAST (P32775), GLGX_ECOLI (P15067), GLGX_HAEIN (P45178), GLGX_MYCTU (Q10767), ISOA_PSEAY (P10342), ISOA_PSESP (P26501), MA1S_YEAST (P53341), MA3S_YEAST (P38158), MA6S_YEAST (P07265), MAL1_DROME (P07191), MAL2_DROME (P07190), MAL3_DROME (P07192), MALT_AEDAE (P13080), MALT_BACTQ (P80072), MALT_CANAL (Q02751), MALZ_ECOLI (P21517), MAXS_YEAST (P40884), MAYS_YEAST (P40439), MAZS_YEAST (P53051), NEPU_BACST (P38940), NEPU_THEVU (Q08751), O16G_BACCE (P21332), O16G_BACCO (Q45101), O16G_BACSP (P29093), O16G_BACTR (P29094), PULA_KLEAE (P07811), PULA_KLEPN (P07206), TREC_BACSU (P39795), TREC_ECOLI (P28904), Y042_MYCTU (Q10768), Y043_MYCTU (Q10769), YAEF_SCHPO (Q09854), YDD2_SCHPO (Q10427) ========= Family 14 ========= Description: Beta-amylases (EC 3.2.1.2) PROSITE: PDOC00414 3D structure status: Available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Known taxonomic range: eukaryotae, prokaryotae. Note: a Glu is proposed as a catalytic residue, but it is not known if it is the nucleophile or the proton donor. AMYB_ARATH (P25853), AMYB_BACCE (P36924), AMYB_BACCI (P06547), AMYB_HORVU (P16098), AMYB_IPOBA (P10537), AMYB_MAIZE (P55005), AMYB_PAEPO (P21543), AMYB_SECCE (P30271), AMYB_SOYBN (P10538), AMYB_THETU (P19584), AMYB_WHEAT (P93594) ========= Family 15 ========= Description: Glucoamylases (EC 3.2.1.3). PROSITE: PDOC00646 3D structure status: Available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: Glu Catalytic proton donor: Glu Clan: None Known taxonomic range: eukaryotae, prokaryotae. AMYG_ARXAD (P42042), AMYG_ASPAK (P23176), AMYG_ASPNG (P04064), AMYG_ASPOR (P36914), AMYG_ASPSH (P22832), AMYG_CLOSP (P29761), AMYG_HORRE (Q03045), AMYG_NEUCR (P14804), AMYG_RHIOR (P07683), AMYG_SACFI (P08017), AMYG_YEAST (P08019), AMYH_SACDI (P04065), AMYH_SACFI (P26989), AMYI_SACDI (P29760) ========= Family 16 ========= Description: Mainly bacterial beta-glucanases (EC 3.2.1.73) (lichenases). PROSITE: PDOC00794 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Glu (experimental) Catalytic proton donor: Glu (experimental) Clan: GH-B Known taxonomic range: prokaryotae. AGAR_STRCO (P07883), CGKA_ALTCA (P43478), E13B_BACCI (P23903), GUB_BACAM (P07980), GUB_BACBR (P37073), GUB_BACLI (P27051), GUB_BACSU (P04957), GUB_CLOTM (P29716), GUB_FIBSU (P17989), GUB_PAEMA (P23904), GUB_PAEPO (P45797), GUB_RHOMR (P45798), XYND_RUMFL (Q53317) ========= Family 17 ========= Description: Glucan endo-1,3-beta-glucosidases (EC 3.2.1.39) and lichenases (EC 3.2.1.73). PROSITE: PDOC00507 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Glu Catalytic proton donor: Glu Clan: GH-A Known taxonomic range: eukaryotae. Note: currently has only been found in plants and in fungi. BGL2_CANAL (P43070), BGL2_YEAST (P15703), E131_SOLTU (P52400), E132_ARATH (P33157), E132_SOLTU (P52401), E133_SOLTU (P52402), E13A_HORVU (P34742), E13A_LYCES (Q01412), E13A_SOYBN (Q03773), E13B_BRACM (P49236), E13B_HEVBR (P52407), E13B_HORVU (P15737), E13B_LYCES (Q01413), E13B_MAIZE (P49237), E13B_NICPL (P23431), E13B_PEA (Q03467), E13B_PHAVU (P23535), E13B_PRUPE (P52408), E13B_SOYBN (P52395), E13B_TOBAC (P15797), E13B_WHEAT (P52409), E13C_HORVU (Q02126), E13C_TOBAC (P23432), E13D_HORVU (Q02437), E13D_TOBAC (P23433), E13E_HORVU (Q02438), E13E_TOBAC (P23546), E13F_HORVU (Q02439), E13F_TOBAC (P27666), E13G_TOBAC (P23547), E13H_TOBAC (P36401), E13I_TOBAC (P52396), E13J_TOBAC (P52397), E13K_TOBAC (P52398), E13L_TOBAC (P52399), EA6_ARATH (Q06915), GUB2_HORVU (P12257), GUB_NICPL (P07979) ========= Family 18 ========= Description: Chitinases (EC 3.2.1.14), endo-beta-n-acetylglucosaminidases (EC 3.2.1.96) and di-N-acetylchitobiases. PROSITE: PDOC00839 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: carbonyl oxygen of C-2 acetamido group of substrate Catalytic proton donor: Glu Clan: None Known taxonomic range: eukaryotae, prokaryotae, viridae. CHI1_APHAL (P32470), CHI1_BACCI (P20533), CHI1_CANAL (P46876), CHI1_COCIM (P54196), CHI1_RHINI (P29025), CHI1_RHIOL (P29026), CHI1_STROI (P29115), CHI2_CANAL (P40953), CHI2_COCIM (P54197), CHI2_RHIOL (P29027), CHI2_STROI (P29116), CHI3_CANAL (P40954), CHI4_TRIHA (P48827), CHIA_ALTSO (P32823), CHIA_ARATH (P19172), CHIA_CICAR (P36908), CHIA_CUCSA (P17541), CHIA_PHAAN (P29024), CHIA_SERMA (P07254), CHIA_TOBAC (P29060), CHIA_VITVI (P51614), CHIB_SERMA (P11797), CHIB_TOBAC (P29061), CHID_BACCI (P27050), CHIE_BETVU (P36910), CHIT_BRUMA (P29030), CHIT_CAEEL (Q11174), CHIT_MANSE (P36362), CHIT_NPVAC (P41684), CHIT_NPVOP (O10363), CHIT_SACER (P14529), CHIT_STRLI (P36909), CHIT_STRPL (P11220), CHIT_YEAST (P29029), CHIX_STROI (Q05638), CHLY_HEVBR (P23472), CHLY_PARTH (P23473), CONB_CANEN (P49347), DIAC_BOVIN (Q01458), DIAC_HUMAN (Q01459), DIAC_RAT (Q01460), EBA1_FLAME (P36911), EBA2_FLAME (P36912), EBA3_FLAME (P36913), EBAG_FLASP (P80036), EBAG_STRPL (P04067), GP39_BOVIN (P30922), GP39_HUMAN (P36222), KTXA_KLULA (P09805), OGP_BOVIN (Q28042), OGP_HUMAN (Q12889), OGP_MESAU (Q60557), OGP_MOUSE (Q62010), OGP_PAPAN (P36718), OGP_PIG (Q28990), OGP_SHEEP (Q28542) ========= Family 19 ========= Description: Chitinases (EC 3.2.1.14). PROSITE: PDOC00620 3D structure status: Available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae, prokaryotae. AGI_URTDI (P11218), CHI1_CASSA (P29137), CHI1_GOSHI (Q39799), CHI1_HORVU (P11955), CHI1_ORYSA (P24626), CHI1_PEA (P21225), CHI1_SOLTU (P52403), CHI1_TOBAC (P08252), CHI2_BRANA (Q09023), CHI2_GOSHI (Q39785), CHI2_HORVU (P23951), CHI2_ORYSA (P25765), CHI2_PEA (P21226), CHI2_SOLTU (P52404), CHI2_TOBAC (P24091), CHI3_SOLTU (P52405), CHI3_TOBAC (P29059), CHI4_BRANA (Q06209), CHI4_PHAVU (P27054), CHI4_SOLTU (P52406), CHI5_PHAVU (P36361), CHI6_POPTR (P16579), CHI8_POPTR (P16061), CHIA_LYCCI (Q40114), CHIA_LYCES (Q05539), CHIA_MAIZE (P29022), CHIB_LYCES (Q05540), CHIB_MAIZE (P29023), CHIB_PEA (P21227), CHIB_POPTR (P29031), CHIB_VITVI (P51613), CHIC_LYCES (Q05538), CHIC_POPTR (P29032), CHID_LYCES (Q05537), CHIP_BETVU (P42820), CHIP_TOBAC (P17513), CHIQ_TOBAC (P17514), CHIT_ARATH (P19171), CHIT_DIOJA (P80052), CHIT_PETHY (P29021), CHIT_PHAVU (P06215), CHIT_SOLTU (P05315), CHIX_PEA (P36907), CHLY_CARPA (P81241), IAMY_COILA (P15326) ========= Family 20 ========= Description: Beta-hexosaminidases (EC 3.2.1.52) and chitobiases (EC 3.2.1.52). PROSITE: None 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: carbonyl oxygen of C-2 acetamido group of substrate Catalytic proton donor: Glu Clan: None Known taxonomic range: eukaryotae, prokaryotae. Note: Two Glu are proposed as catalytic residues. CHB_SERMA (Q54468), CHB_VIBHA (P13670), HEX1_CANAL (P43077), HEX1_ENTHI (P49009), HEXA_DICDI (P13723), HEXA_HUMAN (P06865), HEXA_MOUSE (P29416), HEXA_PORGI (P49008), HEXB_ALTSO (P49007), HEXB_FELCA (P49614), HEXB_HUMAN (P07686), HEXB_MOUSE (P20060), HEXC_BOMMO (P49010), HEX_VIBVU (Q04786), STRH_STRPN (P49610) ========= Family 21 ========= Description: DELETED. ========= Family 22 ========= Description: Lysozymes type C (EC 3.2.1.17) and alpha-lactalbumins. PROSITE: PDOC00119 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Asp Catalytic proton donor: Glu Clan: None Known taxonomic range: eukaryotae. LCAA_HORSE (P08334), LCAB_HORSE (P08896), LCA_BOVIN (P00711), LCA_CAMDR (P00710), LCA_CAPHI (P00712), LCA_CAVPO (P00713), LCA_EQUAS (P28546), LCA_FELCA (P37154), LCA_HUMAN (P00709), LCA_MACEU (Q06655), LCA_MACGI (P19122), LCA_MACRG (P07458), LCA_MOUSE (P29752), LCA_ORNAN (P30805), LCA_PAPCY (P12065), LCA_PIG (P18137), LCA_RABIT (P00716), LCA_RAT (P00714), LCA_SHEEP (P09462), LYC1_ANAPL (P00705), LYC1_CAPHI (P37713), LYC1_PIG (P12067), LYC1_RAT (P00697), LYC1_TACAC (P37156), LYC2_CAPHI (P37714), LYC2_ONCMY (P11941), LYC2_PIG (P12068), LYC2_RAT (Q05820), LYC3_ANAPL (P00706), LYC3_PIG (P12069), LYCK_SHEEP (P80190), LYCM_MOUSE (P08905), LYCN_BOVIN (P80189), LYCP_MOUSE (P17897), LYC_ALLNI (P79687), LYC_ANOGA (Q17005), LYC_ASTRU (P37715), LYC_AXIAX (P12066), LYC_BOMMO (P48816), LYC_BOVIN (P04421), LYC_CALJA (P79158), LYC_CAMDR (P37712), LYC_CERAE (P30200), LYC_CHICK (P00698), LYC_CHRAM (P22910), LYC_COLAN (P79698), LYC_COLLI (P00708), LYC_COLVI (P00700), LYC_COTJA (P00701), LYC_EQUAS (P11375), LYC_FELCA (P37155), LYC_GORGO (P79179), LYC_HORSE (P11376), LYC_HUMAN (P00695), LYC_HYACE (P05105), LYC_HYLLA (P79180), LYC_HYPCU (P50717), LYC_LOPCA (P00699), LYC_LOPLE (P24364), LYC_MACMU (P30201), LYC_MELGA (P00703), LYC_MIOTA (P79806), LYC_NASLA (P79811), LYC_NUMME (P00704), LYC_OPIHO (Q91159), LYC_ORTVE (P00707), LYC_PAPAN (P00696), LYC_PAVCR (P19849), LYC_PHACO (P00702), LYC_PHAVE (P49663), LYC_PONPY (P79239), LYC_PREEN (P07232), LYC_PSEPE (P21776), LYC_PYGNE (P79847), LYC_RABIT (P16973), LYC_SAGOE (P79268), LYC_SAISC (P79294), LYC_SHEEP (P17607), LYC_SYRRE (P24533), LYC_TRINI (P50718), LYC_TRIVU (P51782), LYSA_DROME (P37157), LYSB_DROME (Q08694), LYSD_DROME (P29614), LYSE_DROME (P37159), LYSP_DROME (P29615), LYSS_DROME (P37160), LYSX_DROME (P37161) ========= Family 23 ========= Description: Lysozymes type G (EC 3.2.1.17). PROSITE: None 3D structure status: Available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: Glu Clan: None Known taxonomic range: eukaryotae. Note: only found in birds so far. LYG_ANSAN (P00718), LYG_CHICK (P27042), LYG_CYGAT (P00717), LYG_STRCA (P00719) ========= Family 24 ========= Description: Phage lysozymes (EC 3.2.1.17). PROSITE: None 3D structure status: Available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: viridae. LYCV_BPP22 (P09963), LYCV_BPPH2 (P11187), LYCV_BPPHV (P13003), LYCV_BPPZA (P07540), LYCV_BPT4 (P00720), VG05_BPT4 (P16009) ========= Family 25 ========= Description: Lysozymes (EC 3.2.1.17). PROSITE: PDOC00737 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae, prokaryotae, viridae. LYCA_BPCP1 (P15057), LYCA_BPCP7 (P19385), LYCA_BPCP9 (P19386), LYCA_BPMV1 (P33486), LYCH_CHASP (P00721), LYCM_STRGL (P25310), LYC_CLOAB (P34020), YEGX_ECOLI (P76421) ========= Family 26 ========= Description: Mainly mannan endo-1,4-beta-mannosidases (EC 3.2.1.78). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Glu (experimental) Catalytic proton donor: Glu (experimental) Clan: GH-A Known taxonomic range: prokaryotae. Note: formerly known as cellulase family I. GUNH_CLOTM (P16218), MANA_PIRSP (P55296), MANA_PSEFL (P49424), MANA_RHOMR (P49425), MANB_BACSM (P16699), MANB_BACSU (P55278), MANB_PIRSP (P55297), MANC_PIRSP (P55298) ========= Family 27 ========= Description: Alpha-galactosidases (EC 3.2.1.22), alpha-N- acetylgalactosaminidases (EC 3.2.1.49) and isomalto-dextranases (EC 3.2.1.94). PROSITE: PDOC00443 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: GH-D Known taxonomic range: eukaryotae and prokaryotae. AGAL_ASPNG (P28351), AGAL_COFAR (Q42656), AGAL_CYATE (P14749), AGAL_HUMAN (P06280), AGAL_MOUSE (P51569), IMD_ARTGO (Q44052), MEL1_YEAST (P04824), MEL2_YEAST (P41945), MEL5_YEAST (P41946), MEL6_YEAST (P41947), NAGA_HUMAN (P17050) ========= Family 28 ========= Description: Polygalacturonases (EC 3.2.1.15). PROSITE: PDOC00415 3D structure status: Not available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae, prokaryotae. MPA2_CRYJA (P43212), PEHX_ERWCH (P15922), PGL1_ARATH (P49062), PGL1_ASPNG (P26213), PGL1_COLLN (Q00446), PGL1_ERWCA (P18192), PGL1_SCLSC (Q12708), PGL2_ARATH (P49063), PGL2_ASPNG (P26214), PGL2_ASPTU (P19805), PGL2_ERWCA (P26509), PGL3_ASPNG (Q12554), PGLA_ASPFL (P41749), PGLB_ASPFL (P41750), PGLR_ACTCH (P35336), PGLR_AGRTU (P27644), PGLR_ASPOR (P35335), PGLR_ASPPA (P49575), PGLR_BRANA (P35337), PGLR_BURSO (P20041), PGLR_COCCA (P26215), PGLR_FUSMO (Q07181), PGLR_GOSBA (Q39766), PGLR_GOSHI (Q39786), PGLR_LYCES (P05117), PGLR_MAIZE (P26216), PGLR_MALDO (P48978), PGLR_MEDSA (Q40312), PGLR_OENOR (P24548), PGLR_PERAE (Q02096), PGLR_PRUPE (P48979), PGLR_TOBAC (Q05967), PGLS_MAIZE (P35338), PGLT_MAIZE (P35339), PGLX_ASPTU (Q00293), PGLX_COCCA (Q00359), PGLX_YEAST (P47180), RHGA_ASPAC (Q00001) ========= Family 29 ========= Description: Alpha-L-fucosidases (EC 3.2.1.51). PROSITE: PDOC00385 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae. FUCO_CAEEL (P49713), FUCO_CANFA (P48300), FUCO_DICDI (P10901), FUCO_HUMAN (P04066), FUCO_RAT (P17164) ========= Family 30 ========= Description: Mammalian glucosylceramidases (EC 3.2.1.45). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Retained anomeric configuration (probable) Catalytic nucleophile/base: Glu (experimental) Catalytic proton donor: Glu (inferred) Clan: GH-A Known taxonomic range: eukaryotae. GLCM_HUMAN (P04062), GLCM_MOUSE (P17439) ========= Family 31 ========= Description: Very diverse, contains alpha-glucosidases (EC 3.2.1.20), a glucoamylase (EC 3.2.1.3), sucrase-isomaltases (EC 3.2.1.48 / EC 3.2.1.10). PROSITE: PDOC00120 3D structure status: Not available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae. AGLU_ASPNG (P56526), AGLU_ASPOR (Q12558), AGLU_BETVU (O04931), AGLU_CANTS (P29064), AGLU_HORVU (Q43763), AGLU_MUCJA (Q92442), AGLU_SPIOL (O04893), AGLU_TETPY (O00906), AMYG_DEBOC (P22861), LYAG_HUMAN (P10253), LYAG_MOUSE (P70699), SUIS_HUMAN (P14410), SUIS_RABIT (P07768), SUIS_RAT (P23739), YAJ1_SCHPO (Q09901), YB79_YEAST (P38138) ========= Family 32 ========= Description: Invertases (EC 3.2.1.26), inulinases (EC 3.2.1.7), and levanases (EC 3.2.1.65). PROSITE: PDOC00532 3D structure status: Not available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae, prokaryotae. CSCA_ECOLI (P40714), FRUA_STRMU (Q03174), INU1_KLUMA (P28999), INV1_DAUCA (P26792), INV1_HANAN (P40912), INV1_LYCES (P29000), INV1_MAIZE (P49175), INV1_PEA (Q43089), INV1_YEAST (P10594), INV2_DAUCA (Q39692), INV2_YEAST (P00724), INV3_DAUCA (Q39693), INV3_YEAST (P10595), INV4_YEAST (P10596), INV5_YEAST (P10597), INV7_YEAST (P07635), INVA_MAIZE (P49174), INVA_PHAAU (P29001), INVA_ZYMMO (P35636), INVB_DAUCA (P80065), INV_DEBOC (P24133), RAFD_ECOLI (P16553), SACC_BACSU (P05656), SCRB_BACSU (P07819), SCRB_KLEPN (P27217), SCRB_LACLA (Q04937), SCRB_PEDPE (P43471), SCRB_SALTY (P37075), SCRB_STAXY (Q05936), SCRB_STRMU (P13522), SCRB_VIBAL (P13394), SCRB_ZYMMO (P22632) ========= Family 33 ========= Description: Sialidases (EC 3.2.1.18). PROSITE: None 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Tyr+Glu Catalytic proton donor: ? Clan: GH-E Known taxonomic range: eukaryotae, prokaryotae. 8511_TRYCR (P18269), 8512_TRYCR (P18270), 8513_TRYCR (P18271), NANH_BACFR (P31206), NANH_CLOPE (P10481), NANH_CLOSE (P29767), NANH_CLOSO (P15698), NANH_MICVI (Q02834), NANH_SALTY (P29768), NANH_VIBCH (P37060), TCNA_TRYCR (P23253) ========= Family 34 ========= Description: Influenza neuraminidases (sialidases) (EC 3.2.1.18). PROSITE: None 3D structure status: Available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Tyr+Glu Catalytic proton donor: ? Clan: GH-E Known taxonomic range: viridae. NRAM_IABAN (P06818), NRAM_IABDA (P03481), NRAM_IACAO (P26143), NRAM_IACHI (P11485), NRAM_IACKQ (P09573), NRAM_IACKR (P09574), NRAM_IADA1 (P03479), NRAM_IADBU (Q07570), NRAM_IADCH (Q07571), NRAM_IADGE (P03480), NRAM_IADH2 (Q07572), NRAM_IADM2 (Q07573), NRAM_IADU3 (Q07599), NRAM_IAFPW (P18881), NRAM_IAGFN (Q07574), NRAM_IAHA1 (Q07575), NRAM_IAHAL (Q07576), NRAM_IAHCO (P08327), NRAM_IAHGD (Q07577), NRAM_IAHJI (Q07578), NRAM_IAHK1 (P08326), NRAM_IAHMI (Q07579), NRAM_IAHNO (Q07580), NRAM_IAHO3 (Q09104), NRAM_IAHO4 (Q09105), NRAM_IAHSO (Q07581), NRAM_IAHTE (Q07582), NRAM_IAKIE (P31348), NRAM_IALEN (P31349), NRAM_IAMAE (Q07583), NRAM_IAME1 (P03471), NRAM_IAME2 (P03475), NRAM_IANT6 (P03473), NRAM_IAPAR (P06819), NRAM_IAPUE (P03468), NRAM_IAQIT (Q07584), NRAM_IARI5 (P03484), NRAM_IARUE (P31510), NRAM_IASH2 (P03478), NRAM_IASWK (Q09106), NRAM_IATKL (Q07585), NRAM_IATKP (P03477), NRAM_IATKR (P03476), NRAM_IATOK (P06820), NRAM_IATRA (P03472), NRAM_IAUDO (P03483), NRAM_IAUSS (P03469), NRAM_IAVI7 (P03482), NRAM_IAWHM (P05803), NRAM_IAWIL (P03470), NRAM_INBBE (P27907), NRAM_INBHK (P16191), NRAM_INBLE (P03474), NRAM_INBLN (P16193), NRAM_INBMD (P16195), NRAM_INBMF (P16199), NRAM_INBOR (P16201), NRAM_INBSI (P16203), NRAM_INBUS (P16205), NRAM_INBVI (P16207) ========= Family 35 ========= Description: Beta-galactosidases (EC 3.2.1.23). PROSITE: PDOC00910 3D structure status: Not available Reaction stereochemical outcome: Retained anomeric configuration (probable) Catalytic nucleophile/base: Glu (inferred) Catalytic proton donor: Glu (inferred) Clan: GH-A Known taxonomic range: eukaryotae, prokaryotae. BGAL_ASPNG (P29853), BGAL_ASPOF (P45582), BGAL_BRAOL (P49676), BGAL_DIACA (Q00662), BGAL_HUMAN (P16278), BGAL_LYCES (P48980), BGAL_MALDO (P48981), BGAL_MOUSE (P23780), BGAM_HUMAN (P16279), BGLA_XANMN (P48982) ========= Family 36 ========= Description: Alpha-galactosidases (EC 3.2.1.22). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: GH-D Known taxonomic range: eukaryotae, prokaryotae. AGA1_PEDPE (P43467), AGA2_PEDPE (P43469), AGAL_STRMU (P27756), RAFA_ECOLI (P16551), YJU4_YEAST (P39531) ========= Family 37 ========= Description: Trehalases (EC 3.2.1.28). PROSITE: PDOC00717 3D structure status: Not available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae, prokaryotae. TREA_BOMMO (P32358), TREA_CANAL (P52494), TREA_ECOLI (P13482), TREA_HUMAN (O43280), TREA_KLULA (P49381), TREA_RABIT (P19813), TREA_TENMO (P32359), TREA_YEAST (P32356), TREB_YEAST (P35172), TREF_ECOLI (P37196) ========= Family 38 ========= Description: Alpha-mannosidases (EC 3.2.1.24 / EC 3.2.1.114). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae. MA2B_BOVIN (Q29451), MA2B_HUMAN (O00754), MA2B_MOUSE (O09159), MA2X_HUMAN (P49641), MAN1_RAT (P21139), MAN1_YEAST (P22855), MAN2_DROME (Q24451), MAN2_HUMAN (Q16706), MAN2_MOUSE (P27046), MAN2_RAT (P28494), MANA_DICDI (P34098), MANE_PIG (Q28949) ========= Family 39 ========= Description: Mammalian alpha-L-iduronidases (EC 3.2.1.76), and some bacterial beta-xylosidases (EC 3.2.1.37). PROSITE: PDOC00787 3D structure status: Not available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: Glu (inferred) Catalytic proton donor: Glu (inferred) Clan: GH-A Known taxonomic range: eukaryotae, prokaryotae. IDUA_CANFA (Q01634), IDUA_HUMAN (P35475), IDUA_MOUSE (P48441), XYNB_CALSA (P23552), XYNB_THESA (P36906) ========= Family 40 ========= Description: DELETED. Note: corresponds to the plant oncogene rolB from Agrobacterium which was first thought to release indoles from indoxyl-beta-glucosides. More recently rolB has been shown (Nature 379:499-500(1996) to have tyrosine phosphatase activity. ========= Family 41 ========= Description: Cytokinin-beta-glucosidases. PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: prokaryotae. Note: corresponds to Agrobacteium rolC, was charactrized along with rolB which has now been shown (see family 40) not to be a glycosyl hydrolase. It is therefore possible that this family will be deleted in the near future. ROLC_AGRRA (P20403), ROLC_AGRRB (P49408), ROLC_NICGL (P07051) ========= Family 42 ========= Description: Beta-galactosidases (EC 3.2.1.23). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Retained anomeric configuration (probable) Catalytic nucleophile/base: Glu Catalytic proton donor: Glu Clan: GH-A Known taxonomic range: eukaryotae, prokaryotae. BGAL_BACST (P19668) ========= Family 43 ========= Description: Mainly bifunctional beta-xylosidases (EC 3.2.1.37) / alpha-L- arabinofuranosidases (EC 3.2.1.55). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae, prokaryotae. ABNA_ASPNG (P42256), XYLA_CLOSR (P48790), XYLB_BACOV (P49943), XYLB_BUTFI (P45982), XYNB_BACPU (P07129), XYNB_PRERU (P48791), XYND_PAEPO (P45796), YAGH_ECOLI (P77713), YXIA_BACSU (P42293) ========= Family 44 ========= Description: Endoglucanases (EC 3.2.1.4). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: prokaryotae. Note: formerly known as cellulase family J. GUNA_PAELA (P29719), MANB_CALSA (P22533) ========= Family 45 ========= Description: Endoglucanases (EC 3.2.1.4). PROSITE: PDOC00877 3D structure status: Available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: Asp (experimental) Catalytic proton donor: Asp (experimental). Clan: None Known taxonomic range: eukaryotae, prokaryotae. Note: formerly known as cellulase family K. GUN1_USTMA (P54424), GUN5_HUMIN (P43316), GUN5_TRIRE (P43317), GUNB_PSEFL (P18126), GUNK_FUSOX (P45699) ========= Family 46 ========= Description: Chitosanases (EC 3.2.1.132). PROSITE: None 3D structure status: Available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: Asp (experimental) Catalytic proton donor: Glu (experimental) Clan: None Known taxonomic range: prokaryotae. CHIS_BACCI (P33673), CHIS_BACSU (O07921), CHIS_NOCSP (P48846), CHIS_STRSQ (P33665) ========= Family 47 ========= Description: Alpha-mannosidases (EC 3.2.1.113). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae. M121_DROME (P53624), M122_DROME (P53625), MA12_HUMAN (P33908), MA12_MOUSE (P45700), MA12_PENCI (P31723), MA12_RABIT (P45701), MANX_MOUSE (P39098), MNS1_YEAST (P32906), YH04_YEAST (P38888) ========= Family 48 ========= Description: Endoglucanases (EC 3.2.1.4) and cellobiohydrolases (EC 3.2.1.91). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Inverted anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: prokaryotae. Note: formerly known as cellulase family L. GUNA_CALSA (P22534), GUNF_CLOCE (P37698), GUNS_CLOTM (P38686), GUX2_CLOSR (P50900), GUXB_CELFI (P50899) ========= Family 49 ========= Description: Dextranases (EC 3.2.1.11). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae, prokaryotae. DEXT_ARTGO (P70744), DEXT_ARTSP (P39652), DEXT_PENMI (P48845) ========= Family 50 ========= Description: Agarases (EC 3.2.1.81). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: prokaryotae. AGAA_VIBS7 (P48839), AGAB_VIBS7 (P48840) ========= Family 51 ========= Description: Alpha-L-arabinofuranosidases (EC 3.2.1.55). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae, prokaryotae. ABF2_BACOV (Q59219), ABF2_BACSU (P94552), ABFA_ASPNG (P42254), ABFA_BACSU (P94531), ABFA_STRLI (P53627) ========= Family 52 ========= Description: Beta-xylosidases (EC 3.2.1.37). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: prokaryotae. XYA1_BACST (P45702), XYA2_BACST (P45704) ========= Family 53 ========= Description: Endo-1,4-beta-galactanases (EC 3.2.1.89). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Retained anomeric configuration (probable) Catalytic nucleophile/base: Glu (inferred) Catalytic proton donor: Glu (inferred) Clan: GH-A Known taxonomic range: eukaryotae, prokaryotae. GANA_ASPAC (P48842), GANA_PSEFL (P48841), YBAB_BACCI (P48843) ========= Family 54 ========= Description: Alpha-L-arabinofuranosidases (EC 3.2.1.55). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Retained anomeric configuration Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae. ABF1_TRIRE (Q92455), ABFB_ASPNG (P42255), XYL1_TRIKO (P48792) ========= Family 55 ========= Description: Exo- and endo-1,3-glucanases (EC 3.2.1.58 and EC 3.2.1.39). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae. E13B_TRIHA (P53626), EXG1_COCCA (P49426) ========= Family 56 ========= Description: Hyaluronidases (EC 3.2.1.35). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae. HUGA_APIME (Q08169), HUGA_DOLMA (P49371), HUGA_VESVU (P49370), HYA1_CAVPO (P23613), HYA1_HUMAN (P38567), HYA1_MACFA (P38568), HYA1_MOUSE (P48794), HYA1_RABIT (P38566) ========= Family 57 ========= Description: Alpha-amylases (EC 3.2.1.1). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: prokaryotae, archaea. AMY1_DICTH (P09961), AMY_METJA (Q59006), AMY_PYRFU (P49067) ========= Family 58 ========= Description: Endo-N-acetylneuraminidase (EC 3.2.1.129). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: viridae. ENAN_BPK1E (P49714), ENAN_BPK1F (Q04830) ========= Family 59 ========= Description: Galactocerebrosidases (EC 3.2.1.46) PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae. GALC_CANFA (P54804), GALC_HUMAN (P54803), GALC_MOUSE (P54818) ========= Family 60 ========= Description: Endoglucanases (EC 3.2.1.4). 3D structure status: Not available Reaction stereochemical outcome: not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae, prokaryotae, archaea. FRVX_ECOLI (P32153), GUNM_CLOTM (P55742), SGCX_ECOLI (P39366), Y555_METJA (Q57975) ========= Family 61 ========= Description: Endoglucanases (EC 3.2.1.4). 3D structure status: Not available Reaction stereochemical outcome: not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae. CEL1_AGABI (Q00023) ========= Family 62 ========= Description: Alpha-L-arabinofuranosidases (EC 3.2.1.55). 3D structure status: Not available Reaction stereochemical outcome: not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae, prokaryotae. XYNC_PSEFL (P23031) ========= Family 63 ========= Description: Mannosyl-oligosaccharide glucosidases (EC 3.2.1.106). 3D structure status: Not available Reaction stereochemical outcome: not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae. CW41_YEAST (P53008), GCS1_CAEEL (Q19426), GCS1_HUMAN (Q13724) ========= Family 64 ========= Description: Endo-1,3-glucanases (EC 3.2.1.39). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: prokaryotae. E13B_ARTSP (Q59146), E13B_OERXA (P22222) ========= Family 65 ========= Description: Trehalases (EC 3.2.1.28). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: eukaryotae, prokaryotae. ATH1_YEAST (P48016), TREA_EMENI (P78617), Y09S_MYCLE (Q49736), Y09S_MYCTU (Q50724), YCJT_ECOLI (P77154), YVDK_BACSU (O06993), YW11_MYCTU (Q10850) ========= Family 66 ========= Description: Dextranases (EC 3.2.1.11) and cycloisomaltooligosaccharide glucanotransferase (EC 2.4.1.-). PROSITE: None 3D structure status: Not available Reaction stereochemical outcome: Not known Catalytic nucleophile/base: ? Catalytic proton donor: ? Clan: None Known taxonomic range: prokaryotae. CTA1_BACCI (P94286), CTA2_BACCI (P70873), DEXT_STRDO (P39653), DEXT_STRMU (Q54443), DEXT_STRSL (Q59979) ====================== Non-classified enzymes ====================== AGAR_ALTAT (P13734), GUNE_RUMFL (Q05622), HYAL_BPH44 (P15316), LYB_BACSU (P10773) ------------------------------------------------------------------------------